1

Questions relevant to users  of research

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• High priority questions addressed 

• Important outcomes addressed 

• Clinicians and patients involved in setting research agenda 

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4

Accessible full research reports 

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• Appropriate study registration 

• Studies published in full 

• Reporting of studies with disappointing results 

• Open access publication 

2

Appropriate research design, conduct and analysis 

• Studies designed with reference to systematic reviews of existing evidence 

• Adequate steps taken to reduce selection bias, information bias and confounding 

• Optimal, feasible and adaptive study designs  

5

Unbiased and usable research reports 

• Study interventions and outcomes sufficiently described 

• All planned study outcomes reported 

• New research interpreted in the context of systematic assessment of relevant evidence 

3

Efficient research oversight and regulation 

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• Appropriate oversight of research 

• Appropriate regulatory measures 

• Appropriate use of Data Safety & Monitoring Committees 

• Good re-use of data