Standard Development Group: Age Groups for Pediatric Trials
Distinctive response to treatments across the pediatric age-range can be anticipated. Age groups have been used as a proxy marker of exposure for important biological, developmental, and psychological stages and are widely used for population health, clinical care and research. However the approach in paediatrics has been inconsistent, resulting in inadequate data for assessment of the presence of a true age-treatment interaction and clinically applicable decision-making. This standard group aims to provide guidance to trialists on: the importance of considering appropriate age subgroups in trial design; how to approach age subgroup delineation for a condition of interest and the evolving evidence surrounding age-treatment interactions.
Katrina Williams
Affiliation: University of Melbourne, Royal Children’s Hospital and Murdoch Childrens Research Institute, Melbourne, Australia
Denise Thomson
Affiliation: Cochrane Child Health Field, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Iva Seto
Affiliation: Cochrane Child Health Field, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Despina G. Contopoulos-Ioannidis
Affiliation: Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, and Health Policy Research, Palo Alto Medical Foundation Research Institute, Palo Alto, California
John P.A. Ioannidis
Affiliation: Stanford Prevention Research Center, Department of Medicine, and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California
Sarah Curtis
Affiliation: Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Evelyn Constantin
Affiliation: Department of Pediatrics, Montreal Children’s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Gitanjali Batmanabane
Affiliation: World Health Organization, Regional Office for South-East Asia, New Delhi, India
Lisa Hartling
Affiliation: Cochrane Child Health Field, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Terry Klassen
Affiliation: Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada