Standard Development Group: Age Groups for Pediatric Trials 

Distinctive response to treatments across the pediatric age-range can be anticipated. Age groups have been used as a proxy marker of exposure for important biological, developmental, and psychological stages and are widely used for population health, clinical care and research. However the approach in paediatrics has been inconsistent, resulting in inadequate data for assessment of the presence of a true age-treatment interaction and clinically applicable decision-making. This standard group aims to provide guidance to trialists on: the importance of considering appropriate age subgroups in trial design; how to approach age subgroup delineation for a condition of interest and the evolving evidence surrounding age-treatment interactions.

Katrina Williams

Affiliation: University of Melbourne, Royal Children’s Hospital and Murdoch Childrens Research Institute, Melbourne, Australia

 

Denise Thomson

​Affiliation: Cochrane Child Health Field, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

 

Iva Seto

Affiliation: Cochrane Child Health Field, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

 

Despina G. Contopoulos-Ioannidis

Affiliation: Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, and Health Policy Research, Palo Alto Medical Foundation Research Institute, Palo Alto, California

 

John P.A. Ioannidis

Affiliation: Stanford Prevention Research Center, Department of Medicine, and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California

 

Sarah Curtis

Affiliation: Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

 

Evelyn Constantin

Affiliation: Department of Pediatrics, Montreal Children’s Hospital, McGill University Health Centre, Montreal, Quebec, Canada

 

Gitanjali Batmanabane

Affiliation: World Health Organization, Regional Office for South-East Asia, New Delhi, India

 

Lisa Hartling

Affiliation:  Cochrane Child Health Field, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

 

Terry Klassen

Affiliation: Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada