Wed, Dec 09



December StaR Forum - Janneke van 't Hooft, MD, PhD

How can clinical research increase its usefulness to inform clinical practice: assessment of 350 randomised controlled trials in preterm birth research

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December StaR Forum - Janneke van 't Hooft, MD, PhD

Time & Location

Dec 09, 2020, 3:00 p.m. – 4:00 p.m. EST


About the event

Clinical research aims to produce knowledge that supports decisions and provide recommendations for clinical practice. It is absolutely critical that the produced evidence from research is valid, reliable, and meaningful. Unfortunately, evidence suggests that a high proportion of research is not useful, or may even provide false findings, a problem defined as "research waste." Research waste is estimated to consume as much as 85% of the global medical research budget each year and can be found across all stages of research: starting from a research question, to design, to publication and dissemination of findings.

In this webinar we will dive into usefulness of research, inspired by a publication from John Ioannidis entitled "Why most clinical research is not useful?" (Plos Med 2016). We will however focus more on the positive approach: how can we make clinical research more useful?

As a medical doctor in obstetrics I’m confronted daily with the burden of preterm birth, which is the single most important cause of perinatal mortality and morbidity. While the volume of published research on preterm birth is increasing, effective interventions for women and their offspring to actually prevent preterm birth are still lacking. It is therefore timely to evaluate research waste in this area and subsequently increase the quality and value of new research.

Here is a warm-up for your brain: which problem illustrates usefulness?

About the Presenter: 

Janneke van ‘t Hooft, MD and Masters in Clinical Epidemiology, is currently finishing her specialization in obstetrics and gynaecology at the Amsterdam Medical Center, The Netherlands. In 2019-2020 she worked as a Postdoc at the Meta Research and Innovation Center at Stanford (METRICS) supervised by Prof. John Ioannidis and Prof. Steve Goodman. She combines her clinical work with research in which she supervises several PhD students. Her previous research focused on improving evaluation research in obstetrics and gynecology by coordinating the development of core outcome sets and setting (international) research priorities in obstetrics and gynecology.

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